![]() According to the World Health Organization, unintentional poisoning remains a problem for modern society, with several million people affected each year. With various applications including probable uses for hunting and social recognition/promotion within early human groups, poisons have then mostly been used for suicide, pest-control, and assassination since Antiquity and generally up to the Renaissance period. ![]() The utilization of poisons ( compounds causing harm, injury or death) seems to have preceded the invention of writing (beginning of history) by at least 500 years. Keywords: Poisons, Macrocycles, Supramolecular Chemistry, Antidotes, Host-guest Introduction Along this line of research, endogenous "harmful" species are also sequestered by one or more of these supramolecular host molecules, expanding the potential of supramolecular antidotes to diverse therapeutic areas. Cyclodextrins, cucurbiturils, acyclic cucurbituril derivatives, calixarenes, and pillararenes, have been reported to largely impact the effects of toxic compounds, thus extending the current paradigm of small molecule antidotes by adding a new family of macrocyclic compounds to the current arsenal of antidotes. This review focuses on recent developments to reverse or prevent toxic effects of poisons by encapsulation in host molecules. Currently, the majority of poisons are composed of small molecules. Simultaneously, antidotes have become crucial as reversal agents to counteract the effects of a poison, and they are also used today to positively cancel the benefits of a poison after use. Initially considered as deleterious or hazardous substances, the modern era has witnessed the controlled utilization of dangerous poisons in medicine and cosmetics. Poisons always have fascinated humankind. Select the file that you have just downloaded and select import option Reference Manager (RIS). Recent advances in supramolecular antidotes. Yin H, Zhang X, Wei J, Lu S, Bardelang D, Wang R.
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